Psi-Ops: The Mindgate Conspiracy challenges players to use their most powerful weapon--their mind--as they try to master the first action/stealth game to integrate traditional weapons combat with extensive Psi (psychic) mind powers. Combatting a terrorist movement set to overthrow world order, Nick Geller--an elite American Psi-Operative--fights using telekinesis (lifting and throwing objects), pyrokinesis (controlling fire), remote viewing (going "out-of-body" to plan attacks), mind drain (draining Psi energy from enemies), aura view ("seeing" elements that aren't visible in the real world) and mind control (taking control of enemies) to fight against an army of programmed, psychic terrorist super soldiers that will stop at nothing to reach their goal.

As Geller, players must conquer a programmed super soldier army and its psychic agents while using Psi powers. In addition to Psi capabilities, players have access to traditional weapons such as handguns and automatic weaponry. As players strategically navigate seven huge immersive levels within four distinct compounds, they encounter multiple ways to solve missions, which greatly adds to the replay value.